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Recommended citation: Boniolo FS, Rodrigues RC, Delatorre EO, da Silveira MM, Flores VMQ, Berbert-Molina MA. Glycine Betaine Enhances Growth of Nitrogen-Fixing Bacteria Gluconacetobacter diazotrophicus PAL5 Under Saline Stress Conditions. Curr. Microbiol. 2009 Dec 18;59(6):593–9.

Phylodynamics of HIV-1 subtype C epidemic in east Africa

Published in PLOS ONE, 2012

A substantial proportion of subtype C infections in East Africa resulted from dissemination of a single HIV local variant, probably originated in Burundi during the 1960s

Recommended citation: Delatorre EO, Bello G. Phylodynamics of HIV-1 subtype C epidemic in east Africa. PLoS One. 2012 Jul 27;7(7):e41904.

Evidence of multiple introductions and autochthonous transmission of the HIV type 1 CRF02_AG clade in Brazil.

Published in AIDS research and human retroviruses, 2012

CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state

Recommended citation: Delatorre EO, Bello G, Eyer-Silva WA, Chequer-Fernandez SL, Morgado MG, Couto-Fernandez JC. Evidence of multiple introductions and autochthonous transmission of the HIV type 1 CRF02_AG clade in Brazil. AIDS Res. Hum. Retroviruses. 2012 Oct 9;28(10):1369–72.

Spatiotemporal dynamics of the HIV-1 CRF06_cpx epidemic in western Africa

Published in AIDS, 2013

The CRF06_cpx most probably emerged in Burkina Faso in 1979, and from there, it disseminated to Mali and Nigeria (1980s) and later to other west and west-central African countries.

Recommended citation: Delatorre E, Bello G. Spatiotemporal dynamics of the HIV-1 CRF06_cpx epidemic in western Africa. AIDS. 2013 May 15;27(8):1313–20.

Phylodynamics of the HIV-1 epidemic in Cuba

Published in PLOS ONE, 2013

The HIV-1 epidemic in Cuba was a result of the successful introduction of a few strains of different HIV-1 clades that began to circulate at a rather late time of the AIDS pandemic, but then were rapidly disseminated through local transmission networks.

Recommended citation: Delatorre E, Bello G. Phylodynamics of the HIV-1 Epidemic in Cuba. PLoS One. 2013 Sep 9;8(9):e72448.

Tracing the origin and northward dissemination dynamics of HIV-1 subtype C in Brazil

Published in PLOS ONE, 2013

The Brazilian subtype C clade most probably originated in Burundi and was introduced into the Paraná state (southern region) around the middle 1970s, after which it rapidly disseminated to neighboring regions.

Recommended citation: Delatorre E, Couto-Fernandez JC, Guimarães ML, Vaz Cardoso LP, de Alcantara KC, Martins de Araújo Stefani M, et al. Tracing the Origin and Northward Dissemination Dynamics of HIV-1 Subtype C in Brazil. PLoS One. 2013 Sep 12;8(9):e74072.

Spatiotemporal dynamics of the HIV-1 subtype G epidemic in West and Central Africa

Published in PLOS ONE, 2014

Subtype G most probably emerged in Central Africa in 1968 and from there it disseminated to West and West Central Africa at multiple times from the middle 1970s onwards.

Recommended citation: Delatorre E, Mir D, Bello G. Spatiotemporal Dynamics of the HIV-1 Subtype G Epidemic in West and Central Africa. PLoS One. 2014 Jun 11;9(6):e98908.

Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal

Published in PLOS ONE, 2015

Most subtype G sequences from Cape Verde and Portugal branch in a distinct monophyletic clade that probably emerged after a single viral migration from Central Africa into Cape Verde, followed by a rapid dissemination to Portugal.

Recommended citation: de Pina-Araujo IIM, Delatorre E, Guimarães ML, Morgado MG, Bello G. Origin and Population Dynamics of a Novel HIV-1 Subtype G Clade Circulating in Cape Verde and Portugal.PLoS One. 2015 May 20;10(5):e0127384.

Reassessing the origin of the HIV-1 CRF02_AG lineages circulating in Brazil

Published in AIDS research and human retroviruses, 2015

At least five independent introductions of the CRF02-AG lineage from West Africa into Brazil ocurred, and these lineages have been locally disseminating in the Rio de Janeiro state over the past 30 years.

Recommended citation: Delatorre E, Velasco-De-Castro CA, Pilotto JH, Couto-Fernandez JC, Bello G, Morgado MG. Reassessing the Origin of the HIV-1 CRF02_AG Lineages Circulating in Brazil. AIDS Res. Hum. Retroviruses. 2015 Dec;31(12):1230–7.

Zika virus in the Americas: early epidemiological and genetic findings

Published in Science, 2016

A single introduction of ZIKV into the Americas, estimated to have occurred between May-Dec 2013, was responsible for the epidemic.

Recommended citation: Faria NR, Azevedo RSS, Kraemer MUG, Souza R, Cunha MS, Hill SC, et al. Zika virus in the Americas: Early epidemiological and genetic findings. Science. 2016;352(6283):345–9.

High HIV-1 genetic diversity in patients from Northern Brazil

Published in AIDS research and human retroviruses, 2016

The genetic complexity of the HIV-1 epidemic in Northern Brazil is very high and may vary across different northern states, reflecting a complex epidemic with multiple independent viral introductions.

Recommended citation: da Costa CM, Costa de Oliveira CM, Chehuan de Melo YF, Delatorre E, Bello G, Couto-Fernandez JC. High HIV-1 Genetic Diversity in Patients from Northern Brazil. AIDS Res. Hum. Retroviruses. 2016 Sep;32(9):918–22.

Time-scale of minor HIV-1 complex circulating recombinant forms from Central and West Africa

Published in BMC Evolutionary Biology, 2016

HIV-1 CRFs-cpx clades (09_cpx, 11_cpx, 13_cpx, and 45_cpx) have been circulating in Central Africa for a period comparable to other much more prevalent HIV-1 group M lineages.

Recommended citation: Delatorre E, Bello G. Time-scale of minor HIV-1 complex circulating recombinant forms from Central and West Africa. BMC Evol. Biol.. 2016 Dec 16;16(1):249.

Phylodynamics of the major HIV-1 CRF02_AG African lineages and its global dissemination

Published in Infection, Genetics and Evolution, 2016

Most of the current CRF02_AG diversity comes from the dissemination of a few founder strains out of Central Africa into West Africa and Cameroon between the late 1960s and the middle 1980s.

Recommended citation: Mir D, Jung M, Delatorre E, Vidal N, Peeters M, Bello G. Phylodynamics of the major HIV-1 CRF02_AG African lineages and its global dissemination. Infect. Genet. Evol.; 2016;46:190–9.

Tracing the origin of a singular HIV-1 CRF45_cpx clade identified in Brazil

Published in Infection, Genetics and Evolution, 2016

CRF45 Brazilian clade has been circulating in the Southeastern Brazilian region for about 30 years, although its presence was not detected until recently due to its very low prevalence.

Recommended citation: Delatorre E, de Azevedo SSD, Rodrigues-Pedro A, Velasco-de-Castro CA, Couto-Fernandez JC, Pilotto JH, et al. Tracing the origin of a singular HIV-1 CRF45_cpx clade identified in Brazil. Infect. Genet. Evol.; 2016;46:223–32.

High HIV-1 diversity and prevalence of transmitted drug resistance among antiretroviral-naive HIV-infected pregnant women from Rio de Janeiro, Brazil

Published in AIDS research and human retroviruses, 2017

Besides the HIV diversity increase in the Rio de Janeiro metropolitan region, the TDR prevalence found in this population may affect the virological outcome of the standard PMTCT ARV-regimens adopted in Brazil.

Recommended citation: Delatorre E, Silva-de-Jesus C, Couto-Fernandez JC, Pilotto JH, Morgado MG. High HIV-1 Diversity and Prevalence of Transmitted Drug Resistance Among Antiretroviral-Naive HIV-Infected Pregnant Women from Rio de Janeiro, Brazil. AIDS Res. Hum. Retroviruses. 2017 Jan;33(1):68–73.

Zika virus evolution and spread in the Americas

Published in Nature, 2017

ZIKV circulated undetected in multiple American regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections.

Recommended citation: Metsky HC, Matranga CB, Wohl S, Schaffner SF, Freije CA, Winnicki SM, et al. Zika virus evolution and spread in the Americas. Nature. 2017;546(7658):411–5.

HIV-1 Genetic Diversity in Northeastern Brazil: High Prevalence of Non-B Subtypes

Published in AIDS research and human retroviruses, 2017

HIV-1 epidemic spreading in the Northeastern Brazilian region comprised by multiple subtypes and recombinant strains and the molecular epidemiologic pattern in this Brazilian region is much more complex than originally estimated.

Recommended citation: Delatorre E, Couto-Fernandez JC, Bello G. HIV-1 Genetic Diversity in Northeastern Brazil: High Prevalence of Non-B Subtypes. AIDS Res. Hum. Retroviruses. 2017;33(7):639–47.

Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak

Published in Scientific Reports, 2017

All major YFV outbreaks detected in non-endemic South American regions since 2000, including the 2017 Brazilian outbreak, were caused by a new lineage (here called modern-lineage) that replaced all lineages previously circulating.

Recommended citation: Mir D, Delatorre E, Bonaldo M, Lourenço-de-Oliveira R, Vicente AC, Bello G. Phylodynamics of Yellow Fever Virus in the Americas: new insights into the origin of the 2017 Brazilian outbreak. Sci. Rep. 2017;7(1):7385.

Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity

Published in Memórias do Instituto Oswaldo Cruz, 2017

The ancestral ZIKV strain carrying the A188V substitution arose in Southeastern Asia at the early 2000s and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.

Recommended citation: Delatorre E, Mir D, Bello G. Tracing the origin of the NS1 A188V substitution responsible for recent enhancement of Zika virus Asian genotype infectivity. Mem. Inst. Oswaldo Cruz. 2017;112(11):793–5.

An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels

Published in Journal of General Virology, 2018

An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF in this patient, whereas no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).

Inferring population dynamics of HIV-1 subtype C epidemics in Eastern Africa and Southern Brazil applying different Bayesian phylodynamics approaches

Published in Scientific Reports, 2018

Different phylodynamic models based on coalescent and birth-death models support similar epidemic dynamics and exponential growth rates until roughly the mid-1980s for all the CEA sub-epidemics in Eastern Africa and Brazil.

Recommended citation: Mir D, Gräf T, Esteves de Matos Almeida S, Pinto AR, Delatorre E, Bello G. Inferring population dynamics of HIV-1 subtype C epidemics in Eastern Africa and Southern Brazil applying different Bayesian phylodynamics approaches. Sci. Rep. 2018;8(1):8778.

Investigating the Role of Easter Island in Migration of Zika Virus from South Pacific to Americas

Published in Emerging Infectious Diseases, 2018

Zika virus was independently disseminated from French Polynesia into the Americas and Easter Island at around the same time.

Recommended citation: Delatorre E, Fernández J, Bello G. Role of Easter Island in migration of Zika virus from South Pacific to Americas. Emerg Infect Dis. 2018 [date cited].

HIV controllers suppress viral replication and evolution and prevent disease progression following intersubtype HIV-1 superinfection.

Published in AIDS, 2018

Some HIV controllers are able to repeatedly limit replication and evolution of superinfecting viral strains of a different subtype with no signs of disease progression

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Reduction of inflammation and T cell activation after 6 months of cART initiation during acute, but not in early chronic HIV-1 infection.

Published in Retrovirology, 2018

Early initiation of cART in HIV infection can reduce systemic inflammation, but the earlier normalization of the inflammation markers was only observed when cART was initiated in the acute phase of infection.

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Reduction of HIV-1 Reservoir Size and Diversity After 1 Year of cART Among Brazilian Individuals Starting Treatment During Early Stages of Acute Infection.

Published in Frontiers in Microbiology, 2019

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Combination of surveillance tools reveals that Yellow Fever virus can remain in the same Atlantic Forest area at least for three transmission seasons.

Published in Memórias, 2019

We detected the first evidence of YFV re-emergence in the third transmission season (2018-2019) in a dying howler monkey from the central region of the Rio de Janeiro (Brazil) state.

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Distinct YFV Lineages Co-circulated in the Central-Western and Southeastern Brazilian Regions From 2015 to 2018.

Published in Frontiers in Microbiology, 2019

The ongoing YFV outbreak in Southeastern Brazil originated from a dissemination event from Goiás state almost 2 years before its recognition at the end of 2016

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